BNP Rabbit pAb from ELK Biotechnology Read more ›
BNP Rabbit pAb is a research-use antibody from ELK Biotechnology for studying BNP in IHC workflows with listed reactivity for Human. Specifications and supporting documents below should be reviewed when planning the experiment.
Natriuretic peptide B(NPPB) Homo sapiens This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis.
| Specificity | This antibody detects endogenous levels of BNP at Human |
|---|---|
| Validation evidence captions | Immunohistochemical analysis of paraffin-embedded Human Heart Tissue using ILK1 Rabbit polyclonal antibody diluted at 1:200. |
| Collaborator | ELK Biotechnology |
| Partner model | ES20876 |
| Target | BNP |
| Research areas | >>Autophagy - other, >>Autophagy - animal, >>mTOR signaling pathway, >>PI3K-Akt signaling pathway, >>Thermogenesis |
| Reactivity | Human |
| Applications | IHC |
| Conjugation | Unconjugated |
| Dilution range | IHC 1:50-200 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from human BNP AA range: 89-139 |
| Concentration | 1 mg/ml |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Assay type | Antibody validation/application |
| Expression system | Broadly expressed, with highest levels in skeletal muscle, heart and kidney. |
| Purity | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Species | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Human |
| Species | Dilution | Notes |
|---|---|---|
| Human | IHC 1:50-200 | — |
Collaborator meets ABMIUM quality standards and overall product performance standards have been met.
Quality management certification.
For research applications. Not for diagnostic use.
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