BNP Rabbit pAb
BNP Rabbit pAb from ELK Biotechnology Read more ›
Product Description
BNP Rabbit pAb is an ELK Biotechnology antibody for research workflows involving BNP.
Background
Natriuretic peptide B(NPPB) Homo sapiens This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis.
Additional antibody information
| Specificity | This antibody detects endogenous levels of BNP at Human |
|---|---|
| Validation evidence captions | Immunohistochemical analysis of paraffin-embedded Human Heart Tissue using ILK1 Rabbit polyclonal antibody diluted at 1:200. |
Key Facts
| Target | BNP |
| Also known as | Target of rapamycin complex subunit LST8 (TORC subunit LST8) (G protein beta subunit-like) (Gable) (Protein GbetaL) (Mammalian lethal with SEC13 protein 8) (mLST8) |
| Concentration | 1 mg/ml |
| Working concentration | IHC 1:50-200 |
| Species reactivity | Human |
| Observed band | 37kD |
| Cellular localization | Cytoplasm . |
| Purity | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Form / buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.90% sodium azide. |
| Research area | >>Autophagy - other;>>Autophagy - animal;>>mTOR signaling pathway;>>PI3K-Akt signaling pathway;>>Thermogenesis |
| Host species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Tested applications |
IHC |
| Dilution range | IHC 1:50-200 |
| Immunogen | Synthesized peptide derived from human BNP AA range: 89-139 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
Reactivity & Application Validation
1 species| Species | WB | IHC | IF | ELISA | IP | FCM | CHIP |
|---|---|---|---|---|---|---|---|
| Human |
| Species | Dilution | Notes |
|---|---|---|
| Human | IHC 1:50-200 | — |
Specifications
Storage & Stability
Compliance & Certifications
Manufactured under ISO 9001:2015 quality management standards.
Not intended for diagnostic or therapeutic use.