CNTF rabbit pAb
CNTF rabbit pAb from ELK Biotechnology Read more ›
Product Description
CNTF rabbit pAb is an ELK Biotechnology antibody for research workflows involving CNTF.
Background
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010],
Additional antibody information
| Specificity | CNTF protein(A218) detects endogenous levels of CNTF |
|---|---|
| Validation evidence captions | Western blot analysis of 1) Hela, 2)Mouse Brain Tissue, 3)Rat Brain Tissue with CNTF Rabbit pAb diluted at 1:2,000. |
Key Facts
| Target | CNTF |
| Also known as | CNTF; Ciliary neurotrophic factor; CNTF |
| Concentration | 1 mg/ml |
| Working concentration | WB 1:500-1000 |
| Species reactivity | Human;Rat;Mouse |
| Observed band | 30kD |
| Cellular localization | Cytoplasm. |
| Purity | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen. |
| Form / buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Research area | >>Cytokine-cytokine receptor interaction;>>JAK-STAT signaling pathway |
| Host species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Tested applications |
WB |
| Dilution range | WB 1:500-1000 |
| Immunogen | Synthetic Peptide of CNTF |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen. |
Reactivity & Application Validation
3 speciess| Species | WB | IHC | IF | ELISA | IP | FCM | CHIP |
|---|---|---|---|---|---|---|---|
| Human | |||||||
| Rat | |||||||
| Mouse |
| Species | Dilution | Notes |
|---|---|---|
| Human | WB 1:500-1000 | — |
| Rat | — | — |
| Mouse | — | — |
Specifications
Storage & Stability
Compliance & Certifications
Manufactured under ISO 9001:2015 quality management standards.
Not intended for diagnostic or therapeutic use.