CBP rabbit pAb from ELK Biotechnology Read more ›
CBP rabbit pAb is a research-use antibody from ELK Biotechnology for studying CBP in WB, IHC, IF, ELISA workflows with listed reactivity for Human, Mouse, Rat. Specifications and supporting documents below should be reviewed when planning the experiment.
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations invo
| Specificity | CBP Polyclonal Antibody detects endogenous levels of CBP protein. |
|---|---|
| Validation evidence captions | Western Blot analysis of various cells using CBP Polyclonal Antibody diluted at 1:1000 | Western Blot analysis of HT29 cells using CBP Polyclonal Antibody diluted at 1:1000 | Immunofluorescence analysis of HeLa cells, using CBP Antibody. The picture on the right is blocked with the synthesized peptide. | Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using CBP Antibody. The picture on the right is blocked with the synthesized peptide. |
| Collaborator | ELK Biotechnology |
| Partner model | ES1879 |
| Target | CBP |
| Research areas | >>Viral life cycle - HIV-1, >>cAMP signaling pathway, >>HIF-1 signaling pathway, >>FoxO signaling pathway, >>Cell cycle, >>Wnt signaling pathway, >>Notch signaling pathway, >>TGF-beta signaling pathway, >>Adherens junction, >>JAK-STAT signaling pathway, >>Long-term potentiation, >>Melanogenesis, >>Thyroid hormone signaling pathway, >>Glucagon signaling pathway, >>Growth hormone synthesis, secretion and action, >>Huntington disease, >>Tuberculosis, >>Hepatitis B, >>Influenza A, >>Human papillomavirus infection, >>Human T-cell leukemia virus 1 infection, >>Kaposi sarcoma-associated herpesvirus infection, >>Pathways in cancer, >>Viral carcinogenesis, >>MicroRNAs in cancer, >>Renal cell carcinoma, >>Prostate cancer |
| Reactivity | Human,Mouse,Rat |
| Applications | WB,IHC,IF,ELISA |
| Conjugation | Unconjugated |
| Dilution range | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CBP. AA range:1501-1550 |
| Concentration | 1 mg/ml |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Assay type | Antibody validation/application |
| Expression system | Acute myeloid leukemia,Brain,Epithelium, |
| Purity | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Species | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Human | |||||||
| Mouse | |||||||
| Rat |
| Species | Dilution | Notes |
|---|---|---|
| Human | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. | — |
| Mouse | — | — |
| Rat | — | — |
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Collaborator meets ABMIUM quality standards and overall product performance standards have been met.
Quality management certification.
For research applications. Not for diagnostic use.
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