JNK1/2/3 (phospho Thr183/Y185) rabbit pAb from ELK Biotechnology Read more ›
JNK1/2/3 (phospho Thr183/Y185) rabbit pAb is a research-use antibody from ELK Biotechnology for studying JNK1/2/3 in WB, IHC, IF, ELISA workflows with listed reactivity for Human, Mouse, Rat, Chicken/pig/fish(tested by our customer）. Specifications and supporting documents below should be reviewed when planning the experiment.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spl
| Specificity | Phospho-JNK1/2/3 (T183/Y185) Polyclonal Antibody detects endogenous levels of JNK1/2/3 protein only when phosphorylated at T183/Y185. |
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| Collaborator | ELK Biotechnology |
| Partner model | ES1350 |
| Target | JNK1/2/3 |
| Research areas | >>Endocrine resistance, >>MAPK signaling pathway, >>ErbB signaling pathway, >>Ras signaling pathway, >>cAMP signaling pathway, >>FoxO signaling pathway, >>Sphingolipid signaling pathway, >>Mitophagy - animal, >>Autophagy - animal, >>Protein processing in endoplasmic reticulum, >>Apoptosis, >>Apoptosis - multiple species, >>Necroptosis, >>Wnt signaling pathway, >>Osteoclast differentiation, >>Focal adhesion, >>Tight junction, >>Toll-like receptor signaling pathway, >>NOD-like receptor signaling pathway, >>RIG-I-like receptor signaling pathway, >>C-type lectin receptor signaling pathway, >>IL-17 signaling pathway, >>Th1 and Th2 cell differentiation, >>Th17 cell differentiation, >>T cell receptor signaling pathway, >>Fc epsilon RI signaling pathway, >>TNF signaling pathway, >>Neurotrophin signaling pathway, >>Retrograde endocannabinoid signaling, >>Dopaminergic synapse, >>Inflammatory mediator regulation of TRP channels, >>Insulin signaling pathway, >>GnRH signaling pathway, >>Progesterone-mediated oocyte maturation, >>Pr |
| Reactivity | Human,Mouse,Rat,Chicken/pig/fish(tested by our customer） |
| Applications | WB,IHC,IF,ELISA |
| Conjugation | Unconjugated |
| Dilution range | IF: 1:50-200 WB 1:500-2000, IHC 1:50-300 IHC 1:50-300 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | The antiserum was produced against synthesized peptide derived from human JNK1/2/3 around the phosphorylation site of Thr183 and Tyr185. AA range:151-200 |
| Concentration | 1 mg/ml |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Assay type | Antibody validation/application |
| Expression system | Brain,Epithelium,Fetal brain,Lung,Pooled,Testis, |
| Purity | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Species | WB | IHC | IF | ELISA | IP | FCM | ChIP |
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| Mouse | |||||||
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| pig | |||||||
| fish(tested by our customer） |
| Species | Dilution | Notes |
|---|---|---|
| Human | IF: 1:50-200 WB 1:500-2000 | — |
| Mouse | — | — |
| Rat | — | — |
| Chicken | — | — |
| pig | — | — |
| fish(tested by our customer） | — | — |
| Species | Dilution | Notes |
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| Species | Dilution | Notes |
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Collaborator meets ABMIUM quality standards and overall product performance standards have been met.
Quality management certification.
For research applications. Not for diagnostic use.
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