KCC2B rabbit pAb from ELK Biotechnology Read more ›
KCC2B rabbit pAb is a research-use antibody from ELK Biotechnology for studying KCC2B in WB, ELISA workflows with listed reactivity for Human, Rat, Mouse. Specifications and supporting documents below should be reviewed when planning the experiment.
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],
| Specificity | KCC2B Polyclonal Antibody detects endogenous levels of protein. |
|---|
| Collaborator | ELK Biotechnology |
| Partner model | ES10807 |
| Target | KCC2B |
| Research areas | >>ErbB signaling pathway, >>Calcium signaling pathway, >>cAMP signaling pathway, >>HIF-1 signaling pathway, >>Oocyte meiosis, >>Necroptosis, >>Adrenergic signaling in cardiomyocytes, >>Wnt signaling pathway, >>Axon guidance, >>Circadian entrainment, >>Long-term potentiation, >>Neurotrophin signaling pathway, >>Cholinergic synapse, >>Dopaminergic synapse, >>Olfactory transduction, >>Inflammatory mediator regulation of TRP channels, >>Insulin secretion, >>GnRH signaling pathway, >>Melanogenesis, >>Oxytocin signaling pathway, >>Glucagon signaling pathway, >>Aldosterone synthesis and secretion, >>Cushing syndrome, >>Gastric acid secretion, >>Parkinson disease, >>Pathways of neurodegeneration - multiple diseases, >>Amphetamine addiction, >>Tuberculosis, >>Pathways in cancer, >>Proteoglycans in cancer, >>Glioma, >>Diabetic cardiomyopathy, >>Lipid and atherosclerosis |
| Reactivity | Human,Rat,Mouse |
| Applications | WB,ELISA |
| Conjugation | Unconjugated |
| Dilution range | WB 1:500-2000 ELISA 1:5000-20000 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Concentration | 1 mg/ml |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Assay type | Antibody validation/application |
| Expression system | Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle. |
| Purity | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Species | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Human | |||||||
| Rat | |||||||
| Mouse |
| Species | Dilution | Notes |
|---|---|---|
| Human | WB 1:500-2000 ELISA 1:5000-20000 | — |
| Rat | — | — |
| Mouse | — | — |
| Species | Dilution | Notes |
|---|
Collaborator meets ABMIUM quality standards and overall product performance standards have been met.
Quality management certification.
For research applications. Not for diagnostic use.
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