Recombinant Mouse Thrombomodulin (C-6His)
Recombinant Mouse Thrombomodulin (C-6His) from ELK Biotechnology Read more ›
Product Description
Recombinant Mouse Thrombomodulin (C-6His) is an ELK Biotechnology recombinant protein for research use.
Description
Recombinant Mouse Thrombomodulin is produced by our Mammalian expression system and the target gene encoding Leu17-Ser517 is expressed with a 6His tag at the C-terminus.
Background
Thrombomodulin is also known as CD141 antigen and blood dendritic cell antigen 3 (BDCA3), which is encoded by the THBD gene. The deduced amino acid sequence of mouse THBD predicts a signal peptide (aa 1 to 16) and a mature chain (aa 17 to 577) that consists of the following domains: C-type lectin, EGF-like, transmembrane and cytoplasmic. Mouse THBD is corresponding to the extracellular portion of the type I membrane protein. Predominantly synthesized by vascular endothelial cells, THBD inhibits coagulation and fibrinolysis. It functions as a cell surface receptor and an essential cofactor for active thrombin, which in turn activates protein C and thrombinactivatable fibrinolysis inhibitor (TAFI), also known as carboxypeptidase B2 (CPB2). In addition, THBD gene polymorphisims are associated with human disease and THBD plays a role in thrombosis, stroke, arteriosclerosis, and cancer.
Handling information
| Delivery condition | The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below. |
|---|
Key Facts
| Target | Thrombomodulin |
| Also known as | Thrombomodulin; TM; Fetomodulin; CD141; BDCA-3; Thbd |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. |
| Form / buffer | Lyophilized protein |
| Research area | Molecular Biology |
| Specification | PURITY | ENDOTOXIN | BIOACTIVITY |
|---|---|---|---|
| Product QC |
Specifications
Storage & Stability
Compliance & Certifications
Manufactured under ISO 9001:2015 quality management standards.
Not intended for diagnostic or therapeutic use.