COX2/Cyclooxygenase 2 Mouse mAb
COX2/Cyclooxygenase 2 Mouse mAb from ELK Biotechnology Read more ›
Product Description
COX2/Cyclooxygenase 2 Mouse mAb is an ELK Biotechnology antibody for research workflows involving COX2/Cyclooxygenase 2.
Background
Prostaglandin-endoperoxide synthase 2, also known as cyclooxygenase-2 or simply COX-2, is an enzyme that in humans is encoded by the PTGS2 gene. There are two isozymes of COX encoded by distinct gene products: a constitutive COX-1 (this enzyme) and an inducible COX-2, which differ in their regulation of expression and tissue distribution. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. A splice variant of COX-1 termed COX-3 was identified in the CNS of dogs, but does not result in a functional protein in humans. Two smaller COX-1-derived proteins (the partial COX-1 proteins PCOX-1A and PCOX-1B) have also been discovered, but their precise roles are yet to be described.
Additional antibody information
| Validation evidence captions | Immunohistochemical analysis of paraffin-embedded Human Breast Carcinoma using COX2/Cyclooxygenase 2 （EM1160）Mouse mAb diluted at 1:100. |
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Key Facts
| Target | COX2/Cyclooxygenase 2 |
| Also known as | PTGS2 antibody, Prostaglandin H2 synthase 2 antibody, PGHS 2 antibody, Glucocorticoid-regulated inflammatory cyclooxygenase antibody |
| Concentration | 1mg/mL |
| Working concentration | IHC 1:100-200 |
| Species reactivity | Human, Rat, Mouse |
| Observed band | 70kDa |
| Cellular localization | Endoplasmic reticulum, Membrane, Microsome |
| Form / buffer | Antibody solution |
| Research area | Antibody Research |
| Host species | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Tested applications |
IHC |
| Dilution range | IHC 1:100-200 |
| Immunogen | Synthetic Peptide |
Reactivity & Application Validation
3 speciess| Species | WB | IHC | IF | ELISA | IP | FCM | CHIP |
|---|---|---|---|---|---|---|---|
| Human | |||||||
| Rat | |||||||
| Mouse |
| Species | Dilution | Notes |
|---|---|---|
| Human | IHC 1:100-200 | — |
| Rat | — | — |
| Mouse | — | — |
Specifications
Storage & Stability
Compliance & Certifications
Manufactured under ISO 9001:2015 quality management standards.
Not intended for diagnostic or therapeutic use.