CK16 Mouse mAb
CK16 Mouse mAb from ELK Biotechnology Read more ›
Product Description
CK16 Mouse mAb is an ELK Biotechnology antibody for research workflows involving CK16.
Background
Keratin 16 is expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation-related keratins). Keratin 16 is absent in normal breast tissue and in noninvasive breast carcinomas. Only 10% of the invasive breast carcinomas show diffuse or focal positivity. Reportedly, a relatively high concordance was found between the carcinomas immunostaining with the basal cell and the hyperproliferation-related keratins, but not between these markers and the proliferation marker Ki-67. This supports the conclusion that basal cells in breast cancer may show extensive proliferation, and that absence of Ki-67 staining does not mean that (tumor) cells are not proliferating.
Additional antibody information
| Validation evidence captions | IHC staining of human gullet cancer tissue with CK16 mouse mAb(6F6) diluted at 1:200. |
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Key Facts
| Target | CK16 |
| Also known as | Cytokeratin 16, K16, K1CP, keratin 16, KRT16, KRT16A, NEPPK |
| Concentration | 1mg/mL |
| Working concentration | IHC 1:200 |
| Species reactivity | Human, Rat, Mouse |
| Observed band | 51kDa |
| Cellular localization | Intermediate filament |
| Form / buffer | Antibody solution |
| Research area | Antibody Research |
| Host species | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Tested applications |
IHC |
| Dilution range | IHC 1:200 |
| Immunogen | Synthetic Peptide |
Reactivity & Application Validation
3 speciess| Species | WB | IHC | IF | ELISA | IP | FCM | CHIP |
|---|---|---|---|---|---|---|---|
| Human | |||||||
| Rat | |||||||
| Mouse |
| Species | Dilution | Notes |
|---|---|---|
| Human | IHC 1:200 | — |
| Rat | — | — |
| Mouse | — | — |
Specifications
Storage & Stability
Compliance & Certifications
Manufactured under ISO 9001:2015 quality management standards.
Not intended for diagnostic or therapeutic use.