β-Catenin Rabbit pAb
β-Catenin Rabbit pAb from ELK Biotechnology Read more ›
Product Description
β-Catenin Rabbit pAb is an ELK Biotechnology antibody for research workflows involving β-Catenin.
Background
The distinct peripheral cytosolic proteins, alpha, beta and gamma catenin (102, 94 and 86 kDa) are found in many tissues and bind to the conserved cytoplasmic tail domain of the cell adhesion cadherins. Catenins link E cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt1 proto oncogene. The central core region of beta catenin is involved in mediation of cadherin catenin complex interaction with EGFR. Beta-Catenin-mediated signalling is involved at several stages of vertebrate neural development.
Additional antibody information
| Validation evidence captions | Western blot analysis of 1) 3T3, 2)Rat Liver, with β-Catenin Rabbit pAb EA147 diluted at 1:2,000. | Immunohistochemical analysis of paraffin-embedded human breast caricnoma using β-catenin（EA147）Rabbit pAb diluted at 1:500. |
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Key Facts
| Target | β-Catenin |
| Also known as | beta catenin, b-catenin, CTNB1, CTNNB1, FLJ25606, OTTHUMP00000162082 |
| Concentration | 1mg/mL |
| Working concentration | WB 1:1,000 IHC 1:500-1,000 |
| Species reactivity | Mouse, Rat |
| Observed band | 92kDa |
| Cellular localization | Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Nucleus, Synapse |
| Form / buffer | Antibody solution |
| Research area | Antibody Research |
| Host species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Tested applications |
WBIHC |
| Dilution range | WB 1:1,000 IHC 1:500-1,000 |
| Immunogen | Recombinant Protein |
Reactivity & Application Validation
2 speciess| Species | WB | IHC | IF | ELISA | IP | FCM | CHIP |
|---|---|---|---|---|---|---|---|
| Mouse | |||||||
| Rat |
| Species | Dilution | Notes |
|---|---|---|
| Mouse | WB 1:1 | — |
| Rat | — | — |
| Species | Dilution | Notes |
|---|
Specifications
Storage & Stability
Compliance & Certifications
Manufactured under ISO 9001:2015 quality management standards.
Not intended for diagnostic or therapeutic use.