Anti-METRNL Antibody Picoband®

Boster Bio Anti-METRNL Antibody Picoband® catalog # A11383-1. Tested in WB, ELISA applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Meteorin-like/Meteorin-Beta (Metrnl)/IL-41, also known as subfatin and cometin, is a small (~27kDa) secreted cytokine, protein encoded by a gene called meteorin-like (METRNL). Meteorin-like protein (METRNL) is a 311 amino acid (aa) protein that shows 45% homology with Meteorin (in mouse). Meteorin itself is a secreted 30 kDa protein that is expressed in glial and neuronal cells and their precursors during development and in the adult. In the adult Meteorin is primarily expressed by astrocytes. Meteorin promotes neurite outgrowth, glial cell differentiation, and neuronal survival following excitotoxic injury. It also inhibits sprouting angiogenesis and promotes blood vessel maturation. Mouse Meteorin?like protein is synthesized with a 45 amino acid (aa) signal peptide and is selectively expressed in the otic vesicle during inner ear development. Mature mouse Meteorin?like protein shares 79% and 98% aa sequence identity with human and rat Meteorin?like protein, respectively. Alternate splicing generates an additional isoform that lacks the N?terminal 82 amino acids including the signal peptide. The promoter region of the METRNL gene contains a recognition site for the Pax2, Pax5, and Pax8 transcription factors, and Pax2 binds specifically to this region. METRNL is the only gene found within the terminus of the human chromosome 17 q?arm which can be deleted in the rare Ring 17 syndrome.

Product information

Supplier	Boster Bio
ABMIUM evidence status	ABMIUM Verified™ collaborator-tested data
Catalogue reference	A11383-1
Product category	Primary Antibodies
Reactive species	Human
Tested applications	ELISA, Flow Cytometry, IHC, IHC-P, WB
Available conjugations	Unconjugated, Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, Fluoro647
Gene name	METRNL
Protein name	Meteorin-like protein
Immunogen	E.coli-derived human METRNL recombinant protein (Position: K66-D311). Human METRNL shares 78.5% and 79.3% amino acid (aa) sequence identity with mouse and rat METRNL, respectively.
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Purification	Immunogen affinity purified.
Storage	At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.
UniProt	Q641Q3
NCBI Gene ID	284207

Available variants

Conjugation	Size
Unconjugated	100 μg/vial
Biotin	100 μg/vial
Cy3	100 μg/vial
Fluoro488	100 μg/vial
Fluoro550	100 μg/vial
Fluoro594	100 μg/vial
FITC	100 μg/vial
HRP	100 μg/vial
APC	100 μg/vial
PE	100 μg/vial
Fluoro647	100 μg/vial