A Cyclase IV rabbit pAb from ELK Biotechnology Read more ›
A Cyclase IV rabbit pAb is a research-use antibody from ELK Biotechnology for studying A Cyclase IV in WB, ELISA workflows with listed reactivity for Human, Mouse, Rat. Specifications and supporting documents below should be reviewed when planning the experiment.
This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010],
| Specificity | A Cyclase IV Polyclonal Antibody detects endogenous levels of A Cyclase IV protein. |
|---|---|
| Validation evidence captions | Western Blot analysis of Jurkat cells using A Cyclase IV Polyclonal Antibody | Western blot analysis of lysates from Jurkat cells, using ADCY4 Antibody. The lane on the right is blocked with the synthesized peptide. |
| Collaborator | ELK Biotechnology |
| Partner model | ES5070 |
| Target | A Cyclase IV |
| Research areas | >>Purine metabolism, >>Metabolic pathways, >>Endocrine resistance, >>Rap1 signaling pathway, >>Calcium signaling pathway, >>cGMP-PKG signaling pathway, >>cAMP signaling pathway, >>Chemokine signaling pathway, >>Phospholipase D signaling pathway, >>Oocyte meiosis, >>Longevity regulating pathway, >>Longevity regulating pathway - multiple species, >>Adrenergic signaling in cardiomyocytes, >>Vascular smooth muscle contraction, >>Apelin signaling pathway, >>Gap junction, >>Platelet activation, >>Circadian entrainment, >>Thermogenesis, >>Retrograde endocannabinoid signaling, >>Glutamatergic synapse, >>Cholinergic synapse, >>GABAergic synapse, >>Taste transduction, >>Inflammatory mediator regulation of TRP channels, >>Insulin secretion, >>GnRH signaling pathway, >>Ovarian steroidogenesis, >>Progesterone-mediated oocyte maturation, >>Estrogen signaling pathway, >>Melanogenesis, >>Thyroid hormone synthesis, >>Oxytocin signaling pathway, >>Regulation of lipolysis in adipocytes, >>Aldosterone synthesis and secretion, >>Relaxin sig |
| Reactivity | Human,Mouse,Rat |
| Applications | WB,ELISA |
| Conjugation | Unconjugated |
| Dilution range | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ADCY4. AA range:195-244 |
| Concentration | 1 mg/ml |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Assay type | Antibody validation/application |
| Expression system | Detected in the zona glomerulosa and the zona fasciculata in the adrenal gland (at protein level). |
| Purity | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Species | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Human | |||||||
| Mouse | |||||||
| Rat |
| Species | Dilution | Notes |
|---|---|---|
| Human | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. | — |
| Mouse | — | — |
| Rat | — | — |
| Species | Dilution | Notes |
|---|
Collaborator meets ABMIUM quality standards and overall product performance standards have been met.
Quality management certification.
For research applications. Not for diagnostic use.
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