Recombinant Human ALK-1/ACVRL1 Protein (Fc Tag)
Recombinant Human ALK-1/ACVRL1 Protein (Fc Tag) supplied by Elabscience with collaborator-provided technical specifications. Read more ›
["1. Measured by its ability to bind Human ENG-Fc, latent TGFB1-His, mouse ENG-His in functional Elisa. 2. Measured by its ability to inhibit BMP9 induced alkaline phosphatase production by MC3T3E1 mouse chondrogenic cells. David, L. et al. (2007) Blood 109:1953. The ED50 for this effect is typically 5-15 ng/mL in the presence of 2 ng/mL of recombiant human BMP9. ,45-50 kDa"]Product Description
ALK-1/ACVRL1 is the stated recombinant protein target for this Elabscience product. The listing uses collaborator-supplied specifications to support research-use-only protein selection through ABMIUM.
Protein profile: reactive species/source: Human; expression system: HEK293 Cells; physical form: Lyophilized from sterile PBS, pH 7.4<br/>Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.<br/>Please refer to the specific buffer information in the printed manual.; tag: Human ,ALK-1/ACVRL1 ,Recombinant Proteins; predicted molecular weight: 37.4 kDa.
Quality and formulation: purity: > 97 % as determined by reducing SDS-PAGE.; endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method..
Functional evidence: activity: 1. Measured by its ability to bind Human ENG-Fc, latent TGFB1-His, mouse ENG-His in functional Elisa. 2. Measured by its ability to inhibit BMP9 induced alkaline phosphatase production by MC3T3E1 mouse chondrogenic cells. David, L. et al. (2007) Blood 109:1953. The ED<sub>50</sub> for this effect is typically 5-15 ng/mL in the presence of 2 ng/mL of recombiant human BMP9.. In the ABMIUM matrix, collaborator-supplied functional evidence is marked C; unsupported application columns remain N.
Sequence coverage: 37.4 kDa.
Database references: UniProt: NP_000011.2 | NCBI Gene: 94 | Gene symbol: ALK-1/ACVRL1.
Research Use Only.
Key Facts
| Target | ALK-1/ACVRL1 |
| Also known as | ACVRL1, ACVRLK1, ALK-1, ALK1, Activin Receptor-Like Kinase 1, HHT, HHT2, ORW2, SKR3, Serine/Threonine-Protein Kinase Receptor R3, TGF-B Superfamily Receptor Type I, TSR-I |
| Species reactivity | Human |
| Purity | > 97 % as determined by reducing SDS-PAGE. |
| Form / buffer | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Shelf life | 12 months |
| Research area | Signal Transduction, Cardiovascular, Cancer, metabolism, |
| BIOACTIVITY | BINDING | CELL-BASED | IN VIVO | ELISA CAPTURE | |
|---|---|---|---|---|---|
| Human |
Specifications
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Storage & Stability
Compliance & Certifications
Manufactured under ISO 9001:2015 quality management standards.
Manufactured under ISO 14001:2015 quality management standards.
Manufactured under ISO 45001:2018 quality management standards.
Not intended for diagnostic or therapeutic use.
Substance does not appear on the SVHC candidate list.