Recombinant Human ALK-1/ACVRL1 Protein (Fc Tag) supplied by Elabscience with collaborator-provided technical specifications. Read more ›
["1. Measured by its ability to bind Human ENG-Fc, latent TGFB1-His, mouse ENG-His in functional Elisa. 2. Measured by its ability to inhibit BMP9 induced alkaline phosphatase production by MC3T3E1 mouse chondrogenic cells. David, L. et al. (2007) Blood 109:1953. The ED50 for this effect is typically 5-15 ng/mL in the presence of 2 ng/mL of recombiant human BMP9. ,45-50 kDa"]ALK-1/ACVRL1 is the stated recombinant protein target for this Elabscience product. The listing uses collaborator-supplied specifications to support research-use-only protein selection through ABMIUM.
Protein profile: reactive species/source: Human; expression system: HEK293 Cells; physical form: Lyophilized from sterile PBS, pH 7.4<br/>Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.<br/>Please refer to the specific buffer information in the printed manual.; tag: Human ,ALK-1/ACVRL1 ,Recombinant Proteins; predicted molecular weight: 37.4 kDa.
Quality and formulation: purity: > 97 % as determined by reducing SDS-PAGE.; endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method..
Functional evidence: activity: 1. Measured by its ability to bind Human ENG-Fc, latent TGFB1-His, mouse ENG-His in functional Elisa. 2. Measured by its ability to inhibit BMP9 induced alkaline phosphatase production by MC3T3E1 mouse chondrogenic cells. David, L. et al. (2007) Blood 109:1953. The ED<sub>50</sub> for this effect is typically 5-15 ng/mL in the presence of 2 ng/mL of recombiant human BMP9.. In the ABMIUM matrix, collaborator-supplied functional evidence is marked C; unsupported application columns remain N.
Sequence coverage: 37.4 kDa.
Database references: UniProt: NP_000011.2 | NCBI Gene: 94 | Gene symbol: ALK-1/ACVRL1.
Research Use Only.
| Collaborator | Elabscience |
| Partner model | PKSH031899_100ug |
| Target | ALK-1/ACVRL1 |
| Research areas | Signal Transduction, Cardiovascular, Cancer, metabolism |
| Reactivity | Human |
| Purity | >97% by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Shelf life | 12 months |
| Availability | In stock - ships within 2 business days |
| Lead time | 2-3 business days |
| Category | Bioactivity | Binding | Cell-Based | In Vivo | ELISA Capture |
|---|---|---|---|---|---|
| Human |
Collaborator meets ABMIUM quality standards and overall product performance standards have been met.
Quality management certification.
Environmental management certification.
Occupational health and safety management certification.
For research applications. Not for diagnostic use.
REACH compliant.
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