Anticorps primaire fourni par Boster Bio
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Ce gène code pour un membre de la famille des protéines méthyltransférases 6 de l'ARNt. Une protéine similaire chez la levure fait partie d'une méthyltransférase à deux composants, qui est impliquée dans la modification post-traductionnelle qui produit le nucléoside modifié 1-méthyladénosine dans les ARNt. La 1-méthyladénosine modifiée influence la stabilité de la méthionine initiatrice et peut être impliquée dans la réplication du virus de l'immunodéficience humaine de type 1. L'épissage alternatif entraîne de multiples variants de transcrits.
Fully tested in-house by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Espèce | WB | IHC | IHC-P | IHC-F | IF/ICC | Cytométrie en flux | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Aryl hydrocarbon receptor nuclear translocator (ARNT; HIF-1β/HIF1B) is a bHLH-PAS transcriptional partner that links AHR xenobiotic signalling with HIF hypoxia responses. This catalogue-backed ABMIUM record links human ARNT (NCBI Gene 405; UniProt P27540) to research reagents.
Biological function: ARNT forms obligate heterodimers with other bHLH-PAS transcription factors. With ligand-activated AHR it supports xenobiotic-response-element transcription, while heterodimerisation with HIF alpha subunits enables hypoxia-response-element transcription controlling adaptive programmes such as angiogenesis, erythropoiesis and metabolic responses.
