Primärantikörper geliefert von Boster Bio
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Dieses Gen kodiert ein Tumorsuppressorprotein, das Transkriptionsaktivierungs-, DNA-Bindungs- und Oligomerisierungsdomänen enthält. Das kodierte Protein reagiert auf verschiedene zelluläre Stressoren, um die Expression von Zielgenen zu regulieren, wodurch Zellzyklusarrest, Apoptose, Seneszenz, DNA-Reparatur oder Veränderungen im Stoffwechsel induziert werden. Mutationen in diesem Gen sind mit einer Vielzahl menschlicher Krebserkrankungen verbunden, einschließlich erblicher Krebserkrankungen wie dem Li-Fraumeni-Syndrom. Alternatives Splicing dieses Gens und die Verwendung alternativer Promotoren führen zu mehreren Transkriptvarianten und Isoformen. Zusätzliche Isoformen entstehen auch durch die Verwendung alternativer Translationsinitiationskodons aus identischen Transkriptvarianten.
Fully tested in-house by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
