Primärantikörper geliefert von Boster Bio
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LCAT (Lecithin-Cholesterin-Acyltransferase) ist ein Enzym, das freies Cholesterin in Cholesterinester umwandelt. Azoulay et al. (1987) verwendeten einen LCAT-korrespondierenden cDNA-Klon, um den Locus durch Analyse von DNA aus somatischen Zellhybriden und In-situ-Hybridisierung 16q22 zuzuordnen. LCAT spielt eine wichtige Rolle im Lipoproteinstoffwechsel, insbesondere im Prozess des „reversen Cholesterintransports“. Das Enzym wird in der Leber synthetisiert und zirkuliert im Blutplasma als Komplex mit Bestandteilen von High-Density-Lipoprotein (HDL). Cholesterin aus peripheren Zellen wird auf HDL-Partikel übertragen, durch die Wirkung von LCAT auf HDL verestert und in den Kern des Lipoproteins eingebaut. Der Cholesterinester wird dadurch zur Leber transportiert (Jonas, 2000).
Fully tested in-house by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human | ||||||||
| Mouse | ||||||||
| Rat |
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