Primärantikörper geliefert von Boster Bio
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Dieses Gen kodiert ein Zilien-assoziiertes Protein, das zur Kinesin-Familie gehört. Dieses Protein spielt eine Rolle im Sonic-Hedgehog (SHH)-Signalweg durch die Regulation von GLI-Transkriptionsfaktoren. Es fungiert als negativer Regulator des SHH-Signalwegs, indem es eine unangemessene Aktivierung von GLI2 in Abwesenheit des Liganden verhindert, und als positiver Regulator, indem es die Verarbeitung von GLI3 zu seiner Repressorform verhindert. Mutationen in diesem Gen wurden mit verschiedenen Ziliopathien in Verbindung gebracht.
Fully tested in-house by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
