Primärantikörper geliefert von Boster Bio
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Insulin-induziertes Gen 1, auch bekannt als INSIG1, ist ein Protein, das beim Menschen durch das INSIG1-Gen kodiert wird. Dieses Gen kodiert ein Membranprotein des endoplasmatischen Retikulums, das den Cholesterinstoffwechsel, die Lipogenese und die Glukosehomöostase reguliert. Das kodierte Protein besitzt sechs Transmembranhelices, die eine Bindungsstelle für Effektorproteine enthalten. Es bindet an die Sterol-sensing-Domänen des sterolregulatorischen Element-bindenden Protein (SREBP)-Spaltungs-aktivierenden Proteins (SCAP) und der 3-Hydroxy-3-Methylglutaryl-Coenzym-A-Reduktase (HMG-CoA-Reduktase) und ist essentiell für den Sterol-vermittelten Transport dieser beiden Proteine. Es fördert die Retention von SCAP im endoplasmatischen Retikulum und den Ubiquitin-vermittelten Abbau der HMG-CoA-Reduktase. Alternatives Spleißen führt zu mehreren Transkriptvarianten.
Fully tested in-house by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Maus | ||||||||
| Ratte |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.