Primärantikörper geliefert von Boster Bio
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CYP27B1 gehört zur Cytochrom P450 Superfamilie der Enzyme. Die Cytochrom P450 Proteine sind Monooxygenasen, die viele Reaktionen des Arzneimittelstoffwechsels und der Synthese von Cholesterin, Steroiden und anderen Lipiden katalysieren. Das durch dieses Gen kodierte Protein lokalisiert an der inneren mitochondrialen Membran, wo es 25-Hydroxyvitamin D3 an der 1alpha-Position hydroxyliert. Diese Reaktion synthetisiert 1alpha,25-Dihydroxyvitamin D3, die aktive Form von Vitamin D3, die an den Vitamin D-Rezeptor bindet und den Kalziumstoffwechsel reguliert. Somit reguliert dieses Enzym den Spiegel an biologisch aktivem Vitamin D und spielt eine wichtige Rolle bei der Kalziumhomöostase. Mutationen in diesem Gen können zu Vitamin D-abhängiger Rachitis Typ I führen.
Fully tested in-house by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human | ||||||||
| Mouse | ||||||||
| Rat |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.