Stat3 (phospho Tyr705) rabbit pAb from ELK Biotechnology
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Stat3 (phospho Tyr705) rabbit pAb is a research-use antibody from ELK Biotechnology for studying Stat3 in WB, IHC, IF, ELISA, IP workflows with listed reactivity for Human, Mouse, Rat, Pig(Test by out customer). Specifications and supporting documents below should be reviewed when planning the experiment.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper
| Specificity | Phospho-Stat3 (Y705) Polyclonal Antibody detects endogenous levels of Stat3 protein only when phosphorylated at Y705. |
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Fully tested in-house by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Human | |||||||
| Mouse | |||||||
| Rat | |||||||
| Pig(Test by out customer) |
This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
STAT3 identifies signal transducer and activator of transcription 3 in Homo sapiens (Human). This target record connects NCBI Gene 6774, UniProtKB P40763 and related ABMIUM catalogue products.
Biological function: STAT3 is a signal transducer and transcription factor activated downstream of multiple cytokine and growth-factor receptors. Following phosphorylation and dimerisation, STAT3 can translocate to the nucleus and regulate gene expression controlling processes including proliferation, survival, differentiation and immune responses.
