Flt-3 (phospho Tyr842) rabbit pAb from ELK Biotechnology
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Flt-3 (phospho Tyr842) rabbit pAb is a research-use antibody from ELK Biotechnology for studying Flt3 in WB, ELISA workflows with listed reactivity for Human, Mouse. Specifications and supporting documents below should be reviewed when planning the experiment.
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015],
| Specificity | Phospho-Flt-3 (Y842) Polyclonal Antibody detects endogenous levels of Flt-3 protein only when phosphorylated at Y842. |
|---|---|
| Validation evidence captions | Western Blot analysis of 293T-UV cells using Phospho-Flt-3 (Y842) Polyclonal Antibody diluted at 1:1000 | Western blot analysis of lysates from HepG2 cells treated with EGF 200ng/ml 30', using FLT3 (Phospho-Tyr842) Antibody. The lane on the right is blocked with the phospho peptide. |
Fully tested in-house by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Human | |||||||
| Mouse |
This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
FLT3 identifies fms related receptor tyrosine kinase 3 in Homo sapiens (Human). This target record connects NCBI Gene 2322, UniProtKB P36888 and related ABMIUM catalogue products.
