EGFR Mouse mAb from ELK Biotechnology
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EGFR Mouse mAb is a research-use antibody from ELK Biotechnology for studying EGFR in WB, IHC, IF, IP workflows with listed reactivity for Human. Specifications and supporting documents below should be reviewed when planning the experiment.
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades.
| Validation evidence captions | Western blot analysis of 1) A431 ,2) Hela, with EM1134 diluted at 1:2,000. | 1、Input: Hela Cell Lysate 2、IP product: IP dilute 1:200 Western blot analysis: primary antibody : EM1134 1:1,000 Secondary antibody: Goat anti-Mouse IgG, Heavy Chain Specific(S003), 1:5,000 | IF analysis of Hela with EM1134(Left) and DAPI (Right) diluted at 1:100. |
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Fully tested in-house by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Human |
This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
EGFR identifies epidermal growth factor receptor in Homo sapiens (Human). This target record connects NCBI Gene 1956, UniProtKB P00533 and related ABMIUM catalogue products.
Biological function: EGFR is a receptor tyrosine kinase that binds EGF-family ligands and converts extracellular growth signals into intracellular signalling responses. Ligand binding promotes receptor dimerisation and autophosphorylation, activating pathways that regulate cell proliferation, survival, differentiation and migration.
