Human AIM2 (Absent In Melanoma 2) CLIA Kit with collaborator-tested sample matrix evidence from Elabscience.
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Human AIM2 (Absent In Melanoma 2) CLIA Kit from Elabscience is intended for research workflows involving AIM2. Review the listed specifications and supporting documents to confirm compatibility with the intended method.
This product is manufactured by Elabscience and sold through ABMIUM without relabelling.
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AIM2 is absent in melanoma 2, also known as interferon-inducible protein AIM2. It is a cytosolic double-stranded DNA sensor and core component of the AIM2 inflammasome, linking detection of misplaced DNA to innate inflammatory responses.
Biological function: AIM2 binds cytosolic double-stranded DNA through its HIN domain and assembles an inflammasome with the adaptor ASC, enabling caspase-1 activation. This promotes maturation of inflammatory cytokines and gasdermin-dependent pyroptotic cell death as part of innate defence against cytosolic DNA.
