CR3L4 rabbit pAb
Manufactured by:ELK Biotechnology
RUO

CR3L4 rabbit pAb

CR3L4 rabbit pAb from ELK Biotechnology

SKU:
ABM110043
Product type
Primary Antibody
TargetCR3L4
ApplicationsWB, ELISA
Species / reactivityHuman, Mouse, Rat
Expression systemAccording to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According to PubMed:12111373, also expressed in brain, pancreas and skeletal muscle, and at lower levels in small intestine, testis, leukocyte and thymus.
PurityThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Manufacturer provenance

Manufactured by:
ELK Biotechnology
Sold by:
ABMIUM
Fulfilled from:
Manufacturer facility or confirmed fulfilment location

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Product description

CR3L4 rabbit pAb is a research-use antibody from ELK Biotechnology for studying CR3L4 in WB, ELISA workflows with listed reactivity for Human, Mouse, Rat. Specifications and supporting documents below should be reviewed when planning the experiment.

Background

This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],

Additional antibody information

Specificity CR3L4 Polyclonal Antibody detects endogenous levels of protein.
Validation evidence captions Western blot analysis of lysates from A431 cells, primary antibody was diluted at 1:1000, 4°over night
Key facts & specifications
Research areas
>>cGMP-PKG signaling pathway, >>cAMP signaling pathway, >>PI3K-Akt signaling pathway, >>AMPK signaling pathway, >>Longevity regulating pathway, >>Adrenergic signaling in cardiomyocytes, >>TNF signaling pathway, >>Thermogenesis, >>Cholinergic synapse, >>Dopaminergic synapse, >>Insulin secretion, >>Estrogen signaling pathway, >>Melanogenesis, >>Thyroid hormone synthesis, >>Glucagon signaling pathway, >>Aldosterone synthesis and secretion, >>Relaxin signaling pathway, >>Cortisol synthesis and secretion, >>Parathyroid hormone synthesis, secretion and action, >>Insulin resistance, >>Cushing syndrome, >>Growth hormone synthesis, >>Vasopressin-regulated water reabsorption, >>Huntington disease, >>Prion disease, >>Cocaine addiction, >>Amphetamine addiction, >>Alcoholism, >>Hepatitis B, >>Human cytomegalovirus infection, >>Human papillomavirus infection, >>Human T-cell leukemia virus 1 infection, >>Viral carcinogenesis, >>Chemical carcinogenesis - receptor activation, >>Prostate cancer
Host species
Rabbit
Clonality
Polyclonal
Isotype
IgG
Dilution range
WB 1:500-2000 ELISA 1:5000-20000
Immunogen
Synthesized peptide derived from human protein . at AA range: 200-280
Observed band
43kD
Cellular localization
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane ; Single-pass type II membrane protein . May also be located in Golgi apparatus.; [Processed cyclic AMP-responsive element-binding protein 3-like protein 4]: Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. .
Assay type
Antibody validation/application
Source organism
Rabbit
Concentration
1 mg/ml
Working concentration
WB 1:500-2000 ELISA 1:5000-20000
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form / buffer
Liquid
Sequence fragment
AA range: 200-280
Quantity per pack
50µL/100µL
Validation & performance evidence
ABMIUM Validated™ ABMIUM Verified™ Expected performance Not suitable

Application validation matrix

Evidence status by application and model.

SpeciesWBIHCIFELISAIPFCMChIP
Human
Mouse
Rat
Identifiers & database references
Supplier SKU / catalogue number
ES9265
UniProt entry
Q8TEY5
Storage, stability & shipping
Storage conditions
'-20°C/1 year
Long-term storage
'-20°C/1 year
Storage buffer
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Compliance & documents
CE marked
No
ISO certifications
ISO 9001
Datasheet
Open datasheet
Product manual
Open manual
Frequently asked questions
Who manufactured this product?

This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.

Can ABMIUM ship this product internationally?

ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.

Can I check suitability before ordering?

Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.

Is this product for clinical use?

Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.

ELK Biotechnology
£220.00