Manufactured by:ELK Biotechnology
RUO

TNNC1 rabbit pAb

TNNC1 rabbit pAb from ELK Biotechnology

SKU:
ABM104072
Product type
Primary Antibody
TargetTNNC1
ApplicationsWB
Species / reactivityHuman, Mouse
PurityThe antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Manufacturer provenance

Manufactured by:
ELK Biotechnology
Sold by:
ABMIUM
Fulfilled from:
Manufacturer facility or confirmed fulfilment location

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Product description

TNNC1 rabbit pAb is a research-use antibody from ELK Biotechnology for studying TNNC1 in WB workflows with listed reactivity for Human, Mouse. Specifications and supporting documents below should be reviewed when planning the experiment.

Background

Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008],

Additional antibody information

Specificity This antibody detects endogenous levels of TNNC1 at Human/Mouse
Validation evidence captions Western blot analysis of lysates from PC-12 cells, primary antibody was diluted at 1:1000, 4°over night
Key facts & specifications
Research areas
>>Calcium signaling pathway, >>Cardiac muscle contraction, >>Adrenergic signaling in cardiomyocytes, >>Hypertrophic cardiomyopathy, >>Dilated cardiomyopathy
Host species
Rabbit
Clonality
Polyclonal
Isotype
IgG
Dilution range
WB 1:500-2000
Immunogen
Synthesized peptide derived from human TNNC1 AA range: 57-107
Cellular localization
nucleoplasm,mitochondrion,cytosol,troponin complex,actin cytoskeleton,contractile fiber,
Assay type
Antibody validation/application
Source organism
Rabbit
Molecular weight
18kD
Concentration
1 mg/ml
Working concentration
WB 1:500-2000
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Form / buffer
Liquid
Sequence fragment
AA range: 57-107
Quantity per pack
50µL/100µL
Validation & performance evidence
ABMIUM Validated™ ABMIUM Verified™ Expected performance Not suitable

Application validation matrix

Evidence status by application and model.

SpeciesWBIHCIFELISAIPFCMChIP
Human
Mouse
Identifiers & database references
Supplier SKU / catalogue number
ES12618
UniProt entry
P63316
Storage, stability & shipping
Storage conditions
'-20°C/1 year
Long-term storage
'-20°C/1 year
Storage buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Compliance & documents
CE marked
No
ISO certifications
ISO 9001
Datasheet
Open datasheet
Product manual
Open manual
Frequently asked questions
Who manufactured this product?

This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.

Can ABMIUM ship this product internationally?

ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.

Can I check suitability before ordering?

Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.

Is this product for clinical use?

Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.

Research target context

TNNC1troponin C1, slow skeletal and cardiac type

View target guide

TNNC1 identifies troponin C1, slow skeletal and cardiac type in Homo sapiens (Human). This target record connects NCBI Gene 7134, UniProtKB P63316 and related ABMIUM catalogue products.

Organism
Homo sapiens (Human)
NCBI Gene
7134
UniProtKB
P63316
ELK Biotechnology
£220.00