Cleaved-COL1A2 (G1102) rabbit pAb from ELK Biotechnology
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Cleaved-COL1A2 (G1102) rabbit pAb is a research-use antibody from ELK Biotechnology for studying COL1A2 in WB, ELISA workflows with listed reactivity for Human, Rat, Mouse. Specifications and supporting documents below should be reviewed when planning the experiment.
This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008],
| Specificity | Cleaved-COL1A2 (G1102) Polyclonal Antibody detects endogenous levels of fragment of activated COL1A2 protein resulting from cleavage adjacent to G1102. |
|---|---|
| Validation evidence captions | Western Blot analysis of various cells using Cleaved-COL1A2 (G1102) Polyclonal Antibody diluted at 1:1000 | Western Blot analysis of VEC cells using Cleaved-COL1A2 (G1102) Polyclonal Antibody diluted at 1:1000 | Western blot analysis of lysates from Jurkat cells, treated with etoposide 25uM 24h, using Collagen I alpha2 (Cleaved-Gly1102) Antibody. The lane on the right is blocked with the synthesized peptide. |
Fully tested in-house by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Human | |||||||
| Rat | |||||||
| Mouse |
This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
COL1A2 identifies collagen type I alpha 2 chain in Homo sapiens (Human). This target record connects NCBI Gene 1278, UniProtKB P08123 and related ABMIUM catalogue products.
