Human MMP13/Collagenase 3 ELISA Kit PicoKine®
ELISA Kit supplied by Boster Bio Read more ›
Product Description
Collagenase 3 is an enzyme that in humans is encoded by the MMP13 gene. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. The expression of MMP13 in osteoarthritic cartilage and its activity against type II collagen indicates that the enzyme plays a significant role in cartilage collagen degradation and must, therefore, form part of a complex target for proposed therapeutic interventions based on collagenase inhibition. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Product information
| Supplier | Boster Bio |
|---|---|
| ABMIUM evidence status | ABMIUM Verified™ collaborator-tested data |
| Catalogue reference | EK0468 |
| Product category | PicoKine® ELISA Kits |
| Reactive species | Human |
| Tested applications | ELISA |
| Gene name | MMP13 |
| Protein name | Collagenase 3 |
| Sample type | cell culture supernatants, serum and plasma ( heparin). |
| Assay range | 156 pg/ml - 10,000 pg/ml |
| Sensitivity | <5 pg/ml |
| Specificity | Natural and recombinant human total MMP13 |
| Immunogen | Expression system for standard: NS0; Immunogen sequence: L20-C471 |
| Storage | Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.) |
| UniProt | P45452 |
| NCBI Gene ID | 4322 |
Available variants
| Conjugation | Size |
|---|---|
| Not applicable | 96 wells/kit, with removable strips. |
Key Facts
| Target | Collagenase 3 |
| Also known as | CLG3; Matrix metalloproteinase 13; MMP 13; MMP13 |
| Species reactivity | Human |
| Purity | Natural and recombinant human total MMP13 |
| Shelf life | Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.) |
| Sensitivity | <5 pg/ml |
| Detection range | 156 pg/ml - 10,000 pg/ml |
| Sample types |
cell culture supernatantsserum and plasma ( heparin).
See sample validation ›
|
Sample Type Validation
2 sample types| Sample Type | SERUM | PLASMA (EDTA) | URINE | CSF | CELL SUPERNATANT |
|---|---|---|---|---|---|
| cell culture supernatants | |||||
| serum and plasma ( heparin). |
Specifications
Storage & Stability
Compliance & Certifications
Not intended for diagnostic or therapeutic use.