Human Cathepsin B PicoKine® Quick ELISA Kit

Human Cathepsin B PicoKine® Quick ELISA Kit (90 minutes, 96 Tests). Quantitate Human CTSB in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 5pg/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.

Cathepsin B is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSB gene.1, 2 And this gene is mapped to chromosome 8p22.3 The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. Cathepsin B was once suspected as a candidate protease participating in the conversion of beta-amyloid precursor protein into the amyloid plaques found in Alzheimer's disease patients. However, this function is now known to be mediated by BACE1 protease. It is now thought that cathepsin B can degrade beta-amyloid precursor protein into harmless fragments. Thus, it is conceivable cathepsin B may play a pivotal role in the natural defense against Alzheimer's disease.4 Overexpression of cathepsin B has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. The standard product used in this kit is recombinant human Cathepsin B with the molecular mass of 37KDa.

Product information

Supplier	Boster Bio
ABMIUM evidence status	ABMIUM Verified™ collaborator-tested data
Catalogue reference	FEK0670
Product category	Quick ELISA Kits
Reactive species	Human
Tested applications	ELISA
Gene name	CST3
Protein name	Cathepsin B
Sample type	cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)
Assay range	156 pg/ml - 10,000 pg/ml
Sensitivity	<5 pg/ml
Specificity	Natural and recombinant Human CTSB
Immunogen	Expression system for standard: NS0; Immunogen sequence: R18-I339
Storage	Store at 4°C for 6 months. (Ships with gel ice, can store for up to 3 days in room temperature. Refrigerate upon receipt.)
UniProt	P07858
NCBI Gene ID	1508

Available variants

Conjugation	Size
Not applicable	96 wells/kit, with removable strips.