Anti-PI 3 Kinase catalytic subunit alpha/PIK3CA Antibody Picoband®

Boster Bio Anti-PI 3 Kinase catalytic subunit alpha/PIK3CA Antibody Picoband® catalog # PB9314. Tested in Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Phosphatidylinositol-4,5-bisphosphate 3-kinase, also called PIK3CA, is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. PIK3CA gene is mapped to 3q26.32. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate phosphatidylinositols (PtdIns), PtdIns4P andPtdIns(4,5)P2. Recent evidence has shown that the PIK3CA gene is mutated in a range of human cancers. It has been found to be oncogenic and has been implicated in cervical cancers. PIK3CA mutations in breast cancer may be a predictive marker to guide the selection of patients who would benefit from mTOR inhibitor therapy. In addition to that, the presence of PIK3CA mutation may predict response to aspirin therapy for colorectal cancer, indicating power and promise of Molecular Pathological Epidemiology (MPE) approach as well as a complex interaction within the tumor microenvironment in this phenomenon.

Product information

Supplier	Boster Bio
ABMIUM evidence status	ABMIUM Verified™ collaborator-tested data
Catalogue reference	PB9314
Product category	Primary Antibodies
Reactive species	Human
Tested applications	ELISA, Flow Cytometry, IHC, IHC-P, WB
Available conjugations	Unconjugated, Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, Fluoro647
Gene name	PIK3CA
Protein name	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Specificity	No cross reactivity with other proteins.
Immunogen	E.coli-derived human PIK3CA recombinant protein (Position: H936-N1068). Human PIK3CA shares 98% amino acid (aa) sequence identity with mouse PIK3CA.
Host	Rabbit
Clonality	Polyclonal
Isotype	Rabbit IgG
Purification	Immunogen affinity purified.
Storage	Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.
UniProt	P42336
NCBI Gene ID	5290

Available variants

Conjugation	Size
Unconjugated	100 μg/vial
Biotin	100 μg/vial
Cy3	100 μg/vial
Fluoro488	100 μg/vial
Fluoro550	100 μg/vial
Fluoro594	100 μg/vial
FITC	100 μg/vial
HRP	100 μg/vial
APC	100 μg/vial
PE	100 μg/vial
Fluoro647	100 μg/vial