Recombinant Human ACVR2B/ActivinR-IIB Protein (Fc Tag)
Recombinant Human ACVR2B/ActivinR-IIB Protein (Fc Tag) supplied by Elabscience with collaborator-provided technical specifications. Read more ›
["1. Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 0.02-0.1 µg/mL in the presence of 10 ng/mL recombinant Activin A. 2. Immobilized Inhibin Human, Mouse, Rat, Cynomolgus, Rhesus Inhibin beta A/Activin A at 2 μg/ml (100 μl/well) can bind Human ACVR2B hFc, the EC50 of Human ACVR2B hFc is 12-60 ng/mL. ,60-65 kDa"]Product Description
ACVR2B/ActivinR-IIB is the stated recombinant protein target for this Elabscience product. The listing uses collaborator-supplied specifications to support research-use-only protein selection through ABMIUM.
Protein profile: reactive species/source: Human; expression system: HEK293 Cells; physical form: Lyophilized from sterile PBS, pH 7.4<br/>Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.<br/>Please refer to the specific buffer information in the printed manual.; tag: Human ,ACVR2B/ActivinR-IIB ,Recombinant Proteins; predicted molecular weight: 40.0 kDa.
Quality and formulation: purity: > 97 % as determined by reducing SDS-PAGE.; endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method..
Functional evidence: activity: 1. Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED<sub>50</sub> for this effect is typically 0.02-0.1 µg/mL in the presence of 10 ng/mL recombinant Activin A. 2. Immobilized Inhibin Human, Mouse, Rat, Cynomolgus, Rhesus Inhibin beta A/Activin A at 2 μg/ml (100 μl/well) can bind Human ACVR2B hFc, the EC<sub>50</sub> of Human ACVR2B hFc is 12-60 ng/mL.. In the ABMIUM matrix, collaborator-supplied functional evidence is marked C; unsupported application columns remain N.
Sequence coverage: 40.0 kDa.
Database references: UniProt: NP_001097.2 | NCBI Gene: 93 | Gene symbol: ACVR2B/ActivinR-IIB.
Research Use Only.
Key Facts
| Target | ACVR2B/ActivinR-IIB |
| Also known as | ACTR-IIB, ACVR2B, Activin Receptor Type IIB, Activin Receptor Type-2B, BMP Type II Receptor, BMP Type-2 Receptor, BMPR-5, Bone Morphogenetic Protein Receptor Type II, Bone Morphogenetic Protein Receptor Type-2 |
| Species reactivity | Human |
| Purity | > 97 % as determined by reducing SDS-PAGE. |
| Form / buffer | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Shelf life | 12 months |
| Research area | Signal Transduction, Stem cells |
| BIOACTIVITY | BINDING | CELL-BASED | IN VIVO | ELISA CAPTURE | |
|---|---|---|---|---|---|
| Human |
Specifications
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Storage & Stability
Compliance & Certifications
Manufactured under ISO 9001:2015 quality management standards.
Manufactured under ISO 14001:2015 quality management standards.
Manufactured under ISO 45001:2018 quality management standards.
Not intended for diagnostic or therapeutic use.
Substance does not appear on the SVHC candidate list.