AGTR1 rabbit pAb from ELK Biotechnology
Know who made it. See the evidence. Buy through one marketplace.
AGTR1 rabbit pAb is a research-use antibody from ELK Biotechnology for studying AGTR1 in WB, ELISA workflows with listed reactivity for Human, Mouse, Rat. Specifications and supporting documents below should be reviewed when planning the experiment.
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012],
| Specificity | This antibody detects endogenous levels of AGTR1. |
|---|---|
| Validation evidence captions | Western blot analysis of various lysate, antibody was diluted at 1000. Secondary antibody(catalog#:RS0002) was diluted at 1:20000 |
Fully tested in-house by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Human | |||||||
| Mouse | |||||||
| Rat |
This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Angiotensin II receptor type 1 (AGTR1), commonly called the AT1 receptor or AT1R, is a G protein-coupled receptor for angiotensin II and a central signalling component of the renin-angiotensin system. This ABMIUM record links human AGTR1 (NCBI Gene 185; UniProt P30556) to catalogue-backed research products.
Biological function: AGTR1 encodes the type-1 angiotensin II receptor, a G protein-coupled receptor activated by angiotensin II. Curated UniProt evidence describes coupling to Gq-family G proteins, phospholipase C activation and increased cytosolic calcium, supporting angiotensin-II responses involved in vascular tone, blood-pressure regulation and renal sodium handling.
