Human APAF1 (Apoptosis Protease Activating Factor 1) CLIA Kit with collaborator-tested sample matrix evidence from Elabscience.
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Human APAF1 (Apoptosis Protease Activating Factor 1) CLIA Kit from Elabscience is intended for research workflows involving APAF1. Review the listed specifications and supporting documents to confirm compatibility with the intended method.
This product is manufactured by Elabscience and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
APAF1 (apoptotic peptidase activating factor 1; Apaf-1) is a core scaffold of the intrinsic apoptosis pathway. Following mitochondrial cytochrome c release, APAF1 assembles the apoptosome and recruits procaspase-9, linking mitochondrial stress to downstream caspase activation.
Biological function: APAF1 binds cytochrome c and ATP or dATP, then oligomerizes into the apoptosome. Through its CARD domain, the complex recruits and activates procaspase-9, which initiates downstream executioner-caspase signalling including caspase-3 activation.
