ABMIUM target intelligence
asialoglycoprotein receptor 1
Asialoglycoprotein receptor 1 (ASGR1; ASGPR1) is the major hepatocyte subunit of the asialoglycoprotein receptor, a lectin receptor that removes desialylated plasma glycoproteins. This catalogue-backed ABMIUM record links human ASGR1 (NCBI Gene 432; UniProt P07306) to research reagents.
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Research context & evidence
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ASGR1 is a type II transmembrane C-type lectin receptor subunit expressed predominantly on hepatocytes. It recognizes terminal galactose and N-acetylgalactosamine on desialylated glycoproteins and promotes receptor-mediated endocytosis followed by lysosomal degradation, supporting serum glycoprotein homeostasis.
ASGR1/ASGPR1 is studied in hepatic glycoprotein clearance, receptor-mediated endocytosis, hepatocyte biology and liver-directed delivery research. Review each linked ABMIUM product for species, application, assay format and product-level validation before use.
Names used across publications, databases and supplier catalogues.