ABMIUM target intelligence
alpha-2-macroglobulin
Alpha-2-macroglobulin (A2M) is a large circulating plasma protein that functions as a broad-spectrum protease inhibitor. This catalogue-backed target record links A2M nomenclature, identifiers, aliases and ABMIUM products.
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Research context & evidence
Target information is kept separate from product-level validation so you can review the biology and the reagent evidence independently.
Alpha-2-macroglobulin (A2M) inhibits multiple classes of proteases through a bait-region trapping mechanism. Protease cleavage induces a conformational change that encloses the enzyme; A2M also binds and transports a range of cytokines and growth factors.
A2M is studied in protease regulation, plasma protein biology, inflammation and cytokine or growth-factor handling. Reagent selection should account for species, sample type, native versus processed forms, application and product-level validation.
Names used across publications, databases and supplier catalogues.
