IP3R-I (phospho Ser1598) rabbit pAb

IP3R-I (phospho Ser1598) rabbit pAb

IP3R-I (phospho Ser1598) rabbit pAb
Manufactured by:ELK Biotechnology
RUO

IP3R-I (phospho Ser1598) rabbit pAb

IP3R-I (phospho Ser1598) rabbit pAb from ELK Biotechnology

SKU:
ABM108800
Product type
Primary Antibody
TargetIP3 Receptor
ApplicationsIHC, IF, ELISA
Species / reactivityHuman, Mouse, Rat
Expression systemWidely expressed.
PurityThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Manufacturer provenance

Manufactured by:
ELK Biotechnology
Sold by:
ABMIUM
Fulfilled from:
Manufacturer facility or confirmed fulfilment location

Know who made it. See the evidence. Buy through one marketplace.

Product description

IP3R-I (phospho Ser1598) rabbit pAb is a research-use antibody from ELK Biotechnology for studying IP3 Receptor in IHC, IF, ELISA workflows with listed reactivity for Human, Mouse, Rat. Specifications and supporting documents below should be reviewed when planning the experiment.

Background

This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009],

Additional antibody information

Specificity Phospho-IP3R-I (S1598) Polyclonal Antibody detects endogenous levels of IP3R-I protein only when phosphorylated at S1598.
Validation evidence captions Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using Inositol 1,4,5-trisphosphate R1 (Phospho-Ser1598/1588) Antibody | Immunofluorescence analysis of A549 cells, using Inositol 1, 4, 5-trisphosphate R1 (Phospho-Ser1598/1588) Antibody. The picture on the right is blocked with the phospho peptide. | Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma, using Inositol 1, 4, 5-trisphosphate R1 (Phospho-Ser1598/1588) Antibody. The picture on the right is blocked with the phospho peptide.
Key facts & specifications
Research areas
>>Calcium signaling pathway, >>cGMP-PKG signaling pathway, >>Phosphatidylinositol signaling system, >>Oocyte meiosis, >>Autophagy - animal, >>Apoptosis, >>Cellular senescence, >>Vascular smooth muscle contraction, >>Apelin signaling pathway, >>Gap junction, >>Platelet activation, >>NOD-like receptor signaling pathway, >>C-type lectin receptor signaling pathway, >>Circadian entrainment, >>Long-term potentiation, >>Retrograde endocannabinoid signaling, >>Glutamatergic synapse, >>Cholinergic synapse, >>Serotonergic synapse, >>Dopaminergic synapse, >>Long-term depression, >>Inflammatory mediator regulation of TRP channels, >>GnRH signaling pathway, >>Estrogen signaling pathway, >>Thyroid hormone synthesis, >>Oxytocin signaling pathway, >>Glucagon signaling pathway, >>Renin secretion, >>Aldosterone synthesis and secretion, >>Cortisol synthesis and secretion, >>Parathyroid hormone synthesis, secretion and action, >>GnRH secretion, >>Cushing syndrome, >>Growth hormone synthesis, >>Salivary secretion, >>Ga
Also known as
ITPR1; INSP3R1; Inositol 1; 4,5-trisphosphate receptor type 1; IP3 receptor isoform 1; IP3R 1; InsP3R1; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor
Host species
Rabbit
Clonality
Polyclonal
Isotype
IgG
Dilution range
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen
The antiserum was produced against synthesized peptide derived from human Inositol 1,4,5-trisphosphate R1 around the phosphorylation site of Ser1598/1588. AA range:1566-1615
Cellular localization
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, secretory vesicle membrane ; Multi-pass membrane protein . Cytoplasm, perinuclear region . Endoplasmic reticulum and secretory granules (By similarity). .
Assay type
Antibody validation/application
Source organism
Rabbit
Molecular weight
314kD
Concentration
1 mg/ml
Working concentration
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form / buffer
Liquid
Sequence fragment
AA range: 1566-1615
Quantity per pack
50µL/100µL
Validation & performance evidence
ABMIUM Validated™ ABMIUM Verified™ Expected performance Not suitable

Application validation matrix

Evidence status by application and model.

SpeciesWBIHCIFELISAIPFCMChIP
Human
Mouse
Rat
Identifiers & database references
Supplier SKU / catalogue number
ES5964
UniProt entry
Q14643
Storage, stability & shipping
Storage conditions
'-20°C/1 year
Long-term storage
'-20°C/1 year
Storage buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Compliance & documents
CE marked
No
ISO certifications
ISO 9001
Datasheet
Open datasheet
Product manual
Open manual
Frequently asked questions
Who manufactured this product?

This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.

Can ABMIUM ship this product internationally?

ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.

Can I check suitability before ordering?

Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.

Is this product for clinical use?

Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.

ELK Biotechnology
£220.00