CREB3L2 rabbit pAb

CREB3L2 rabbit pAb

CREB3L2 rabbit pAb
Manufactured by:ELK Biotechnology
RUO

CREB3L2 rabbit pAb

CREB3L2 rabbit pAb from ELK Biotechnology

SKU:
ABM106841
Product type
Primary Antibody
TargetCREB3L2
ApplicationsWB, ELISA
Species / reactivityHuman, Mouse, Rat
Expression systemWidely expressed with highest levels in placenta, lung, spleen and intestine, and lowest levels in heart, brain, skeletal muscle, thymus, colon and leukocytes. In fetal tissues, the weakest expression is detected in brain and heart.
PurityThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Manufacturer provenance

Manufactured by:
ELK Biotechnology
Sold by:
ABMIUM
Fulfilled from:
Manufacturer facility or confirmed fulfilment location

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Product description

CREB3L2 rabbit pAb is a research-use antibody from ELK Biotechnology for studying CREB3L2 in WB, ELISA workflows with listed reactivity for Human, Mouse, Rat. Specifications and supporting documents below should be reviewed when planning the experiment.

Background

This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],

Additional antibody information

Specificity CREB3L2 Polyclonal Antibody detects endogenous levels of CREB3L2 protein.
Validation evidence captions Western Blot analysis of various cells using CREB3L2 Polyclonal Antibody | Western Blot analysis of HeLa cells using CREB3L2 Polyclonal Antibody | Western blot analysis of the lysates from 293 cells using CREB3L2 antibody.
Key facts & specifications
Research areas
>>cGMP-PKG signaling pathway, >>cAMP signaling pathway, >>PI3K-Akt signaling pathway, >>AMPK signaling pathway, >>Longevity regulating pathway, >>Adrenergic signaling in cardiomyocytes, >>TNF signaling pathway, >>Thermogenesis, >>Cholinergic synapse, >>Dopaminergic synapse, >>Insulin secretion, >>Estrogen signaling pathway, >>Melanogenesis, >>Thyroid hormone synthesis, >>Glucagon signaling pathway, >>Aldosterone synthesis and secretion, >>Relaxin signaling pathway, >>Cortisol synthesis and secretion, >>Parathyroid hormone synthesis, secretion and action, >>Insulin resistance, >>Cushing syndrome, >>Growth hormone synthesis, >>Vasopressin-regulated water reabsorption, >>Huntington disease, >>Prion disease, >>Cocaine addiction, >>Amphetamine addiction, >>Alcoholism, >>Hepatitis B, >>Human cytomegalovirus infection, >>Human papillomavirus infection, >>Human T-cell leukemia virus 1 infection, >>Viral carcinogenesis, >>Chemical carcinogenesis - receptor activation, >>Prostate cancer
Also known as
CREB3L2; BBF2H7; Cyclic AMP-responsive element-binding protein 3-like protein 2; cAMP-responsive element-binding protein 3-like protein 2; BBF2 human homolog on chromosome 7
Host species
Rabbit
Clonality
Polyclonal
Isotype
IgG
Dilution range
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen
The antiserum was produced against synthesized peptide derived from human CREB3L2. AA range:269-318
Observed band
58kD
Cellular localization
Endoplasmic reticulum membrane ; Single-pass type II membrane protein. ER membrane resident protein. Upon ER stress, translocated to the Golgi apparatus where it is cleaved. The cytosolic N-terminal fragment (processed cyclic AMP-responsive element-binding protein 3-like protein 1) is transported into the nucleus. .; [Processed cyclic AMP-responsive element-binding protein 3-like protein 2]: Nucleus. Upon ER stress, translocated into the nucleus. .
Assay type
Antibody validation/application
Source organism
Rabbit
Concentration
1 mg/ml
Working concentration
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form / buffer
Liquid
Sequence fragment
AA range: 269-318
Quantity per pack
50µL/100µL
Validation & performance evidence
ABMIUM Validated™ ABMIUM Verified™ Expected performance Not suitable

Application validation matrix

Evidence status by application and model.

SpeciesWBIHCIFELISAIPFCMChIP
Human
Mouse
Rat
Identifiers & database references
Supplier SKU / catalogue number
ES2048
UniProt entry
Q70SY1
Storage, stability & shipping
Storage conditions
'-20°C/1 year
Long-term storage
'-20°C/1 year
Storage buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Compliance & documents
CE marked
No
ISO certifications
ISO 9001
Datasheet
Open datasheet
Product manual
Open manual
Frequently asked questions
Who manufactured this product?

This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.

Can ABMIUM ship this product internationally?

ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.

Can I check suitability before ordering?

Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.

Is this product for clinical use?

Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.

ELK Biotechnology
£220.00