MDM2Functional association
UniProt reports direct regulatory interaction with MDM2 leading to TP53 ubiquitination and proteasomal degradation.
ABMIUM target intelligence
tumor protein p53
TP53 identifies tumor protein p53 in Homo sapiens (Human). This target record connects NCBI Gene 7157, UniProtKB P04637 and related ABMIUM catalogue products.
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Research context & evidence
Target information is kept separate from product-level validation so you can review the biology and the reagent evidence independently.
TP53 encodes p53, a multifunctional DNA-binding transcription factor that responds to cellular stress by regulating programmes including cell-cycle arrest, DNA repair and apoptosis. Its activity is controlled by extensive protein interactions and post-translational regulation.
TP53 / p53 is studied in DNA-damage responses, cell-cycle control, apoptosis and cancer biology. Use the catalogue filters below to compare ABMIUM reagents by species, application and validation, and confirm product-level suitability before use.
Names used across publications, databases and supplier catalogues.
These relationships provide research context only. They do not establish product or application suitability.
UniProt reports direct regulatory interaction with MDM2 leading to TP53 ubiquitination and proteasomal degradation.
UniProt reports TP53 interaction with the histone acetyltransferase EP300 in transcriptional regulation.
UniProt reports interaction with HIPK2 in TP53 regulatory complexes.
Interpretation: Identity and identifiers were checked against NCBI and reviewed UniProtKB. Biological function and listed interactions are conservatively paraphrased from UniProt evidence. Catalogue association does not establish suitability for a specific assay.