ABMIUM target intelligence
autophagy related 4B cysteine peptidase
ATG4B (autophagy related 4B cysteine peptidase), also called cysteine protease ATG4B or autophagin-1, is an ATG4-family cysteine protease central to ATG8-family protein processing during macroautophagy.
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Research context & evidence
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ATG4B is a peptidase family C54 cysteine protease that processes ATG8-family proteins, including LC3 and GABARAP family members, to expose the C-terminal glycine required for lipidation. It also removes lipid modifications from ATG8-family proteins, regulating autophagosome membrane dynamics and autophagic flux.
ATG4B is widely studied in macroautophagy because ATG8-family processing and delipidation influence LC3/GABARAP membrane association, autophagosome maturation and flux. Protease-activity, lipidation and autophagic-flux assays should be interpreted in the context of substrate specificity and other ATG4-family enzymes.
Names used across publications, databases and supplier catalogues.
