ABMIUM target intelligence
interleukin 2 receptor subunit alpha
IL2RA identifies interleukin 2 receptor subunit alpha in Homo sapiens (Human). This target record connects NCBI Gene 3559, UniProtKB P01589 and related ABMIUM catalogue products.
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Research context & evidence
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IL2RA encodes the alpha subunit of the interleukin-2 receptor, also known as CD25. IL2RA binds IL-2 and contributes to formation of the high-affinity IL-2 receptor complex with IL2RB and the common gamma-chain, supporting IL-2-dependent immune signalling and helping regulate regulatory T-cell activity and immune tolerance.
IL2RA/CD25 is widely studied in T-cell activation, regulatory T-cell biology, immune tolerance, cytokine signalling, autoimmunity, transplantation and immuno-oncology. Expression can vary strongly with activation state and cell population, so experimental interpretation should distinguish constitutive regulatory T-cell expression from activation-associated CD25 expression in other lymphocytes.
Names used across publications, databases and supplier catalogues.
