ABMIUM target intelligence
BRCA1 DNA repair associated
BRCA1 (BRCA1 DNA repair associated; breast cancer type 1 susceptibility protein) is a nuclear genome-maintenance protein and E3 ubiquitin ligase central to DNA-damage responses, double-strand-break repair and genomic stability.
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Research context & evidence
Target information is kept separate from product-level validation so you can review the biology and the reagent evidence independently.
BRCA1 forms a functional heterodimer with BARD1 that has E3 ubiquitin-protein ligase activity. The complex participates in cellular responses to DNA damage and helps coordinate DNA double-strand-break repair, homologous recombination, ubiquitin signalling and maintenance of genome integrity.
BRCA1 is a major research target in DNA-damage response, homologous recombination, chromatin and ubiquitin signalling, genome-stability and hereditary cancer biology. Experimental studies commonly examine BRCA1 recruitment, complex formation, repair-pathway choice and the consequences of altered BRCA1 function. Use catalogue filters to assess ABMIUM reagents by species, application and product-level validation.
Names used across publications, databases and supplier catalogues.
