ABMIUM target intelligence
B cell linker
B cell linker (BLNK), also known as B-cell linker protein, SLP-65 and BASH, is a cytoplasmic adaptor that couples activated B-cell receptor signalling to downstream pathways. BLNK is studied in B-cell development, antigen-receptor signalling, calcium mobilisation and lymphocyte activation.
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Research context & evidence
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Following B-cell receptor activation, BLNK is phosphorylated and functions as a signalling scaffold that organizes downstream effectors, including phospholipase C gamma 2, to support calcium mobilisation and kinase signalling required for normal B-cell activation and differentiation.
BLNK reagents support studies of B-cell receptor pathway organization, phosphotyrosine-dependent signalling, PLCG2-linked calcium responses and B-cell maturation. Assay design should account for activation state, cell type and phosphorylation-dependent signalling context.
Names used across publications, databases and supplier catalogues.
