ABMIUM target intelligence
high mobility group box 1
HMGB1 identifies high mobility group box 1 in Homo sapiens (Human). This target record connects NCBI Gene 3146, UniProtKB P09429 and related ABMIUM catalogue products.
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Research context & evidence
Target information is kept separate from product-level validation so you can review the biology and the reagent evidence independently.
HMGB1 is a multifunctional, redox-sensitive chromatin-associated protein. In the nucleus it acts as a DNA chaperone in transcription, replication, chromatin remodelling and DNA repair; extracellular or cytoplasmic HMGB1 can also participate in inflammatory and innate immune signalling.
HMGB1 is widely studied in chromatin biology, DNA damage responses, sterile inflammation, innate immunity, cell stress and tumour biology. Reagent selection should consider cellular compartment, redox/state context, sample type, assay format, application and supporting validation.
Names used across publications, databases and supplier catalogues.
