ABMIUM target intelligence
carbonic anhydrase 3
Carbonic anhydrase 3 (CA3; carbonic anhydrase III/CA-III) is a cytosolic zinc metalloenzyme with carbonic-anhydrase activity and strong tissue enrichment in skeletal muscle. It is studied in muscle physiology, isozyme-specific CO2 hydration and carbonic-anhydrase expression biology.
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Research context & evidence
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CA3 catalyses reversible hydration of carbon dioxide using a zinc cofactor. It is distinguished from other carbonic-anhydrase isozymes by tissue-specific expression, including high abundance in skeletal muscle, making it useful for studies of muscle-associated carbonic-anhydrase biology and isozyme kinetics.
CA3 research focuses on skeletal-muscle expression, carbonic-anhydrase isozyme diversity, CO2/bicarbonate chemistry and muscle-associated protein expression. Experimental work should distinguish CA3 from closely related CA1 and CA2 sequences and activities.
Names used across publications, databases and supplier catalogues.
