ABMIUM target intelligence
carbonic anhydrase 12
Carbonic anhydrase 12 (CA12; carbonic anhydrase XII/CA-XII) is a type I transmembrane zinc metalloenzyme with an extracellular catalytic domain. It is studied in epithelial CO2/bicarbonate handling, extracellular pH regulation and tissue-specific membrane carbonic-anhydrase biology.
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Research context & evidence
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CA12 catalyses reversible hydration of carbon dioxide at the cell surface, generating bicarbonate and protons and contributing to extracellular acid-base handling. Its transmembrane localisation links carbonic-anhydrase catalysis to epithelial transport and pH-regulatory systems.
CA12 research includes epithelial bicarbonate and fluid handling, membrane pH regulation, kidney and secretory-tissue physiology, and context-dependent altered expression in selected tumour systems. Expression observations should not be interpreted as universal diagnostic or therapeutic claims.
Names used across publications, databases and supplier catalogues.
