ABMIUM target intelligence
complement C5
C5 (complement C5) is a complement-system precursor cleaved into C5a and C5b, coupling complement activation to inflammatory signalling and membrane attack complex assembly.
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Research context & evidence
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C5 convertases cleave complement C5 to generate C5a and C5b. C5a is a potent anaphylatoxin and chemoattractant that drives inflammatory leukocyte responses, whereas C5b initiates assembly of the terminal complement complex with C6-C9, leading to membrane attack complex formation.
C5 is used in research on terminal complement activation, C5a-mediated inflammatory signalling, leukocyte recruitment and C5b-dependent membrane attack complex assembly. Experimental design should distinguish intact C5 from its activation products and consider complement activation during sample collection and handling.
Names used across publications, databases and supplier catalogues.
