ABMIUM target intelligence
Bruton tyrosine kinase
BTK (Bruton tyrosine kinase), also known as tyrosine-protein kinase BTK, is a TEC-family non-receptor tyrosine kinase central to B-cell receptor signalling and B-lymphocyte development.
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Research context & evidence
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Following B-cell receptor engagement, BTK is activated at the plasma membrane and phosphorylates PLCG2, promoting calcium mobilization and downstream protein kinase C signalling. This kinase activity is central to B-cell activation, differentiation and immune signalling.
BTK is a core target in studies of B-cell receptor pathways, B-lymphocyte development, kinase signalling and immune-cell activation. Abmium catalogue products linked below should be evaluated for species, sample type, assay format, application and product-specific validation.
Names used across publications, databases and supplier catalogues.
