ABMIUM target intelligence
bone morphogenetic protein 10
Bone morphogenetic protein 10 (BMP10; BMP-10) is a secreted TGF-beta superfamily ligand with prominent cardiovascular biology. It signals through type I BMP/activin receptors, particularly ACVRL1/ALK1, to regulate SMAD-dependent programmes involved in cardiac and vascular development.
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Research context & evidence
Target information is kept separate from product-level validation so you can review the biology and the reagent evidence independently.
BMP10 is synthesized as a preproprotein and proteolytically processed to a mature secreted ligand. Reviewed UniProt supports signalling through ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6 with activation of SMAD1, SMAD5 and SMAD8. Curated evidence links BMP10 to maintenance of embryonic cardiomyocyte proliferation and regulation of heart morphogenesis, while endothelial responses include control of migration and growth.
BMP10 is studied in cardiovascular development, cardiomyocyte growth, vascular and endothelial signalling, and BMP-SMAD pathway biology. Its heart-enriched expression and ALK1-linked signalling make it useful for research on cardiac morphogenesis and vascular homeostasis. For ABMIUM reagents, confirm species, assay format, application and product-level validation before use.
Names used across publications, databases and supplier catalogues.
