ABMIUM target intelligence
BCL2 associated X, apoptosis regulator
BAX (BCL2 associated X, apoptosis regulator; apoptosis regulator BAX) is a pro-apoptotic BCL-2 family protein that controls mitochondrial outer-membrane permeabilization during intrinsic apoptosis. This catalogue-backed target record connects verified human BAX identity with Abmium research reagents.
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Research context & evidence
Target information is kept separate from product-level validation so you can review the biology and the reagent evidence independently.
BAX is a pro-apoptotic BCL-2 family effector. Under cellular stress it undergoes activating conformational changes, accumulates at the mitochondrial outer membrane and promotes membrane permeabilization, enabling cytochrome c release and downstream apoptotic signalling. Its activity is regulated within the wider balance of pro- and anti-apoptotic BCL-2 family proteins.
BAX is widely studied in intrinsic apoptosis, mitochondrial membrane permeabilization, cellular stress responses and regulation of survival-versus-death signalling. Researchers use BAX measurements and perturbations to investigate how mitochondrial apoptotic commitment is controlled. Use the catalogue filters below to confirm species, assay format, application and product-level validation for each Abmium reagent.
Names used across publications, databases and supplier catalogues.
