ABMIUM target intelligence
aryl hydrocarbon receptor nuclear translocator
Aryl hydrocarbon receptor nuclear translocator (ARNT; HIF-1β/HIF1B) is a bHLH-PAS transcriptional partner that links AHR xenobiotic signalling with HIF hypoxia responses. This catalogue-backed ABMIUM record links human ARNT (NCBI Gene 405; UniProt P27540) to research reagents.
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Research context & evidence
Target information is kept separate from product-level validation so you can review the biology and the reagent evidence independently.
ARNT forms obligate heterodimers with other bHLH-PAS transcription factors. With ligand-activated AHR it supports xenobiotic-response-element transcription, while heterodimerisation with HIF alpha subunits enables hypoxia-response-element transcription controlling adaptive programmes such as angiogenesis, erythropoiesis and metabolic responses.
ARNT/HIF-1β is studied in AHR-mediated xenobiotic signalling, HIF-dependent hypoxia responses, transcription-factor dimerisation and environmental-response biology. Review species, assay format, application and product-level validation for each linked ABMIUM reagent.
Names used across publications, databases and supplier catalogues.
