ABMIUM target intelligence
arachidonate 5-lipoxygenase
ALOX5 (arachidonate 5-lipoxygenase), widely known as 5-lipoxygenase, 5-LO or 5-LOX, is a lipid-oxidising enzyme that initiates leukotriene biosynthesis from arachidonic acid. Researchers study ALOX5 in eicosanoid signalling, leukocyte biology and inflammatory mediator production.
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Research context & evidence
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ALOX5 catalyses conversion of arachidonic acid to 5-hydroperoxyeicosatetraenoic acid (5-HPETE) and then leukotriene A4 (LTA4), a branch-point intermediate for downstream leukotrienes. This places 5-LOX at a central enzymatic step in leukotriene generation.
ALOX5/5-LOX is widely investigated in leukotriene biosynthesis, inflammatory and allergic signalling, innate-immune lipid metabolism and pharmacological modulation of the 5-lipoxygenase pathway. Experimental interpretation should distinguish ALOX5 abundance, localisation and catalytic activity.
Names used across publications, databases and supplier catalogues.
