ABMIUM target intelligence
aldehyde dehydrogenase 7 family member A1
ALDH7A1 (aldehyde dehydrogenase 7 family member A1), also known as alpha-aminoadipic semialdehyde dehydrogenase or antiquitin, is a cytosolic and mitochondrial aldehyde dehydrogenase. Researchers study ALDH7A1 in aldehyde detoxification, lysine-degradation biology and pyridoxine-dependent epilepsy.
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Research context & evidence
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ALDH7A1 is an aldehyde dehydrogenase with cytosolic and mitochondrial isoforms. It protects cells from oxidative stress by metabolising lipid-peroxidation-derived aldehydes and is also linked to the alpha-aminoadipic semialdehyde step of human lysine degradation.
ALDH7A1 research focuses on aldehyde detoxification, oxidative stress, lysine-degradation pathways, subcellular enzyme localisation and the molecular basis of pyridoxine-dependent epilepsy. Experimental studies should distinguish total protein abundance from compartment-specific and catalytic effects.
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